The refectory of the convent of Ognissanti is famous for the large fresco painted in 1488 by Domenico Ghirlandaio. Besides the Last Supper fresco and its sinopia, the refectory also preserves a fine doorway and a lavabo , both dated 1488, and an Annunciation of the early 15th century.
In the adjacent church are two other fine frescoes by Ghirlandaio: St Jerome (1480) and an early work by the artist representing the Madonna of Mercy with the Deposition of Christ , which were painted for the Vespucci family.
The cloister leading to the refectory has frescoes of the Life of St Francis dating from the early 17th century by Florentine artists, including Jacopo Ligozzi and Giovanni da San Giovanni.